Pyrogens and Fever
نویسنده
چکیده
of scanninig electron microscopes, perlhaps with a list of companies wlhich manu-factture the iinstrtunien-t. However this is a minor omission in a most enjoyable an(d useftul book. This volume presents the work of a small internatioinal conference on pyrogens an(l fever sponsored by the Ciba Foundation and lheld in London in July 1970. The purpose of the symposium was to review some of the areas in wlhich recent researclh into the nature of pyrogens or their meclhanism of action lhas contributed significantly to our un(derstan(ling of the pathogenesis of fever. Tlle volume, therefore, is in no way a comprelhensive review of the subject of fever, but the chapters contain current tlhinking in a number of important areas wllich slhouldl be of interest botlh to investigators and students of the field. Two clhapters (leal primarily witlh endotoxin. The one on the clhemistry of bacterial pyrogen is a particularly fine summary of current knowledge of the structure and properties of this complex and pervasive lipopolysacclharide, wllile the otlher deals briefly witlh some significant immunological features of endo-toxins. The subject of endogenous, or leuckocyte, pyrogen is the focus of several papers. Evidence is reviewed for the key role of this molectule in experimental fevers in animals and man, and topics covered in some detail inclucde mechanisms and pathways for its production by cells, current information on its structure and methods for puirification andl quantitation. Data are also presented to imPlicate this pyrogen in the fevers seen in various lhypersensitivity states and after aclministration of certain endogenous, pyrogenic steroids, suclh as etio-cholanolone. Neuroplhysiological mechianisms for fever are tlle subject of two papers wlhiclh includle discussions of the possible role of ions andl amines as regulator substances, the central action of salicylate, and some stuclies of sites of temperature regulation in the brain. The dliscussionis wlhiclh follow eaclh paper are quite extensive and provide informative and often provocative comments. Altlhouglh certain topics of major importance receive brief attention and otlhers are (letailecl beyond the interest of general readlers, the volume presents current tlhinking on the relation of tlle patlhogeniesis of fever to various experimental situations. It should be a useful source for stu(lents and interesting rea(ling for physicians wlho are curious about fever.
منابع مشابه
Fever: Links with an ancient receptor
Recent advances have provided evidence that prostaglandin E2 mediates the generation of fever in response to interleukin-1 or lipopolysaccharide and have reinforced the similarities of signaling downstream of these two pyrogens.
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In a study of the febrile responses of rabbits to repeated intravenous injections of pyrogenic substances from Eberthella typhosa, Serratia marcescens, and Pseudomonas aeruginosa, the following observations were made: 1. A characteristic pattern of response to daily injections of the same dose of pyrogenic material was noted. This consisted of a progressive diminution in febrile response during...
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Prostaglandin (PG) E2 is a potent hyperthermic agent and has been assigned an intermediary function in the response of thermoregulatory neurons to pyrogens. Though attractive, this idea has been challenged on several grounds. The present study confirms that brain PGE2 synthesis increases during fever, the time course of the elevation according with a causative role of the compound. Our experime...
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Fevers are relatively common in rheumatic disease, largely due to the fact that the inflammatory process is driven by inflammatory mediators that function as endogenous pyrogens. Since the immune system's sensors cannot accurately distinguish between endogenous and exogenous (pathogen-derived) pyrogens a major challenge for physicians and rheumatologists has been to decipher patterns of clinica...
متن کاملPersonal Practice Antipyretic Therapy
Fever is among the most common manifestations of disease and antipyresis is one of the most usual therapeutic intervention undertaken. A variety of microbial products including endotoxins and exotoxins are recognized as exogenous pyrogens which induce host cells to produce mediators known as endogenous pyrogens. The best studied endogenous pyrogen is interleukin 1, others include tumor necrosis...
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عنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 45 شماره
صفحات -
تاریخ انتشار 1972